What are the treatment options for oral cancer? Early detection can significantly change what treatment options a doctor may decide to pursue. Treatment for early-stage oral cancer usually involves a surgical resection of the diseased tissue. If the cancerous tissue is large, surgery to remove the diseased tissue may involve removing a large portion of the tongue, lower jaw or throat. When the disease metastasizes, or spreads, to other areas of the body, your doctor may require chemotherapy or radiation in addition to surgical removal of the diseased tissue.